Mirtazapine: Sleepy at Low, Awake at High Doses

“Why Mirtazapine Makes You Sleepy at 15mg but NOT at 30mg” “Mirtazapine is

the only antidepressant that knocks you out at low doses… and wakes you up at high doses.

Here’s why.” “At 15mg, the drug barely touches serotonin or noradrenaline.

What it does hit hard is H1 histamine receptors — and that’s what causes the heavy sedation,

the munchies, and the ‘I slept 12 hours but feel hungover’ effect.” “But once you go

to 30mg or 45mg, something flips. The H1 blockade is still there, but now noradrenergic

and serotonergic release increases, which actually becomes activating, improving mood and

energy — and making it less sedating.” “So if someone wants sleep? Use 15mg.