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Quetiapine 25mg: Sedative, Not Antipsychotic

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Created December 29, 2025

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Video Transcript

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Quetiapine at 25mg isn’t an antipsychotic—at this dose, it’s more like a powerful sedative

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through antihistamine! Given 25mg for sleep or anxiety? You're not being treated for psychosis.

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Quetiapine is a shape-shifter medication, doing different jobs at different doses.

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At lower doses such as 25mg or 50mg, it doesn’t really mess with dopamine. Instead,

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it’s all about that histamine H1 receptor hit. That’s why it knocks you out,

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revs up your appetite, and gives you that heavy, deep sleep everyone talks about.

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Bump up the dose to 300mg or more? And it's a whole different story—welcome to the antipsychotic

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zone, where the dopamine blockade is the real deal. Same drug,

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