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Repro-Immunologic Causes of Pregnancy Loss

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Created December 15, 2025

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Lets discuss the Repro-Immunologic Causes of Pregnancy Loss & Infertility “Reproductive immunology

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explains how a mother’s immune system learns to accept a genetically foreign embryo. When this process

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is disrupted, it can lead to infertility, IVF failure, miscarriages, preterm birth,

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and complications like pre-eclampsia. There are 5 immune categories, from least to most

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severe: 1. Alloimmune issues – when parents are too genetically

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similar, triggering immune activation against the placenta. 2.

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APAS – immune-related blood clotting that blocks blood flow to the embryo. 3.

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Autoimmune pregnancy immunity – antibodies cause inflammation in early pregnancy. 4.

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