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The Role of Adenosine in Sleep Quality

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Created November 10, 2025

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Video Transcript

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What determines how well we sleep and the quality of our wakeful state? Turns out that’s

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governed by two forces. The first force is a chemical force. It’s called adenosine.

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Adenosine is a molecule in our nervous system and body that builds up the longer we are awake.

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So if you've just slept for eight or nine or ten really deep restful hours, adenosine is going

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to be very low in your brain and body. If, however, you’ve been awake

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for 10, 15, or more hours, adenosine levels are going to be

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much higher. Adenosine creates a sort of sleep drive or a sleep hunger.

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