Understanding Alloimmune Disorders in Pregnancy

“Let’s talk about Category 1 of Reproimmunologic Disorders—the Alloimmune Disorder. This happens when

a couple’s HLA tissue types are too genetically similar. As a result, the embryo may closely

match the mother’s genetics. When this occurs, the mother’s immune system may fail

to develop proper tolerance and can become activated against the paternal contribution or

the placenta, interfering with implantation. This immune response often leads to very

early pregnancy loss. The good news? ✨ With proper evaluation and targeted care,

many immune-related pregnancy losses are treatable. Understanding the cause brings clarity—and

hope is real.”