Understanding Lamotrigine in Mental Health

“Lamotrigine is one of the most misunderstood medications in mental health… so let’s break it

down.” “Uniquely, Lamotrigine stabilises mood from the depressive side — not the manic

side. It helps prevent the long, low crashes of Bipolar II,

and helps mood stability.” “Mechanism? It calms overactive glutamate signalling and stabilises voltage-gated

sodium channels — reducing mood swings without oversedation.” “That’s why it’s loved:

✔💡 it lifts depressive episodes ✔⚡ keeps mood steadier over months ✔🌅 has a clean

cognitive profile — no fog, no weight gain.” “But there’s a catch Lamotrigine must

be increased slowly, there's a rare but serious rash risk, including Stevens-Johnson Syndrome.""