Esophageal Papillomas: Morphology and Causes

MORPHOLOGY Gross: Usually small polypoid lesions with a warty surface Benign papillary

proliferation of the squamous epithelium with fibrovascular core of lamina propria Vacuolated cells

with morphological features of koilocytes can be seen without atypical nuclear features

Usually exophytic, but can be flat/endophytic OTHER HIGH YIELD POINTS Result from mucosal

irritation, caused by GERD, trauma, or HPV infection, stimulating a hyper-regenerative

response Typically, in distal esophagus in the US population, but in Asian population,

more frequently seen in the mid esophagus