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Holoprosencephaly: A Rare Brain Defect

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Created November 11, 2025

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Video Transcript

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Your brain is supposed to split into two halves, but sometimes, it just doesn't.

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This is a rare birth defect called holoprosencephaly, and it happens in the first few weeks of pregnancy.

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The fetal brain fails to divide into two separate hemispheres. Instead of two ventricles,

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there's just one. This can cause severe facial anomalies, sometimes even a single,

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central eye, a condition known as cyclopia. It’s a stark example of what can go wrong

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during neurodevelopment, when millions of cells are migrating to build the brain. It’s a reminder

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of how incredibly complex and fragile our first few weeks of life truly are.

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