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Sickle Cell Anemia: A Genetic Misstep

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Created October 5, 2025

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Video Transcript

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One tiny mistake in your genetic code can literally change the shape of your cells.

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Inside your red blood cells, you have a protein called hemoglobin that carries oxygen.

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Normally, it keeps your cells nice, round, and flexible.

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But in sickle cell anemia, there's a single error in the protein's recipe—just one

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wrong amino acid out of hundreds. This tiny mistake makes the hemoglobin proteins super sticky.

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They start clumping together into long, stiff fibers, forcing the entire cell to warp into

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a rigid crescent or "sickle" shape. These stiff cells can't carry oxygen well and get stuck

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in tiny blood vessels.

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